Gen. Henry Rangel Silva will replace Carlos Mata Figueroa, according to the state-run AVN news agency. Chavez, who called Rangel a "good soldier," made the announcement Friday in the central city of Guanare, the agency reported.
The United States added Rangel to its kingpin list in 2008 for allegedly providing support to the Revolutionary Armed Forces of Colombia, commonly known as the FARC.
A statement from the Treasury Department then said that the general "materially assisted the narcotics trafficking activities of the FARC," and pushed for more cooperation between the Venezuelan government and the leftist rebels.
Since 2003, the U.S. government has considered the FARC a "significant foreign narcotics trafficker."
The action froze whatever assets Rangel may have under U.S. jurisdiction and prohibited citizens from doing business with him.
He is not the only Venezuelan official designated by the United States as a drug kingpin.
In September, the Treasury Department added lawmaker Freddy Bernal -- a Chavez loyalist -- and three other officials to the list.
All were accused of allegedly providing support to the FARC, which has been at war with the Colombian government since the 1960s. While severely weakened in recent years, the guerrilla group continues to carry out kidnappings and attack security forces.
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